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Aeroi
unsupp0rted
Only 79… far from a complete human experience. It’s incredibly sad how little time we get here, especially the best of us.
CWuestefeld
I'd MUCH rather consider the completeness of my experience based on what I was able to experience, rather than how long I'd lived for.
Sorry for the tangent, but this is a pet peeve of mine. From my perspective, it seems like our modern quest for safety in all things has the effect of wrapping the whole world, and ourselves, in bubble wrap. The goal seems to be to extend that number as far as possible, without regard to how the life that we experience during that period is diminished by all the safeguards.
It bothers me that we've made it a mantra, telling each other "have a safe trip", or "be safe", and so on. I can't remember anyone saying "have the richest experience you can manage".
unsupp0rted
The longer your lifespan, the more chances you have to waste chunks of it in a rut of zero experience, but have time to work your way out of it.
At just 60 ~ 90 years, a rut of a single decade can take up > 15% of your lifespan.
brettgriffin
This is just a tragic way to view the world, on so may levels: 79 is a great run for anybody. And more importantly, Craig Venter did more in 79 years than most people could do in two or three lifetimes. Lastly, of course, life is literally the longest thing you will ever experience, regardless of how long it lasts.
I learned a lot about Craig Venter after reading My Life Decoded in college. Truly an amazing person.
sigmoid10
>79 is a great run for anybody
Average life expectancy for males in the US is 76.5 years. During the pandemic it dipped below 74. So he was definitely already on the lucky side of the distribution. He also famously once said: "If you want immortality, do something meaningful with your life."
cowsandmilk
> Only 79… far from a complete human experience
It seems you’re judging his life solely on the age when he died rather than all the things he did.
melling
I think he’s really just trying to spur your imagination into imagining if someone like that had lived longer.
Anyway, this conversation has been had repeatedly. Many people seem to be unable to imagine that positive benefit of much longer lives.
Suppose that’s why “Science advances one funeral at a time.”
unsupp0rted
Imagine what a guy like that could do with 79 more years... or 10x of that.
It's not that outlandish: sharks, turtles, etc get far more years than we do.
It's shocking all billionaires aren't devoting all their resources to solving this cosmic crime against humanity.
MyHonestOpinon
Looking at his life. This is as complete human experience as we can hope to get.
kjs3
What is sad is having a world view where the value of a human life is duration, not accomplishment.
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LarsDu88
When I was a kid, I saw an interview with him on 60 minutes. He talked about how he had dropped out of college after letting go of his dreams of being an olympic swimmer. He then served as a medic in Vietnam, and tried to commit suicide by jumping off a navy ship (but of course survived on account of being a near olympic class athlete. With a full head of hair).
Later I saw him in real life give a talk at Cornell University with his old friend geneticist Andy Clark on the human genome. Dude was larger than life, tall, and bald.
A few years later, I moved to San Diego, and got into surfing. Was reading a surfing website, and boom, Craig Venter pops up in an ad for luxury watches! Sailing in the ocean and rocking a Jaeger-LeCoultre watch that was probably worth more than my grad stipend at the time..
A few years after that and I interviewed at one of his companies, Synthetic Genomics. The bioinformatics team had their heads spinning from the number of pivots the company had been doing. They had gone from biofuel production to working on genetically engineering pigs to produce kidneys that could be donated to humans. Lo and behold, within a few years, someone got the idea to actually work.
Basically Venter and his accomplishments have been the background to my entire adult career in biology, genetics, bioinformatics and machine learning.
RIP Craig Venter! Sometimes to get great science to happen you need larger than life personalities!
Aeroi
Great stories. I asked him about the pig thing, after he pivoted from biofuels (I think they raised $150m from Exxon). If I recall he teamed up with another infamous founder Martin, now Martine, Rothblatt who created SeriusXM and United Therapeutics.
gwerbret
Somewhat ironically, he'd spent the last years of his life working on prolonging life [1], and was selling a $25,000 "proactive healthcare service" consultation to anyone who could afford it [2].
1: The company's website, humanlongevity dot com, seems to have been compromised, and as "captcha" will try to have you install a Trojan. So here's the Wikipedia page instead: https://en.wikipedia.org/wiki/Human_Longevity
2: https://fortune.com/2017/02/21/craig-venter-human-longevity/
melling
It appears he had cancer and something about the treatment caused his death.
apitman
Craig Venter was famously involved in the Human Genome Project. He announced the first draft of the human genome alongside President Clinton and Francis Collins.
epistasis
"Involved" in the sense that he took the public data, added in a small amount of his own privately generated data and was trying to get the first assembly. The scientists in the Human Genome Project thought he was going to try to patent the whole thing so others would have to pay him. Back then, it was not clear what was and was not patentable.
So the involvement was in spurring the Human Genome Project to race to an assembly, a massive computational problem that hadn't been fully planned for by the public effort:
https://archive.is/2022.02.14-091753/https://www.nytimes.com...
codeulike
It was essentially a jigsaw puzzle, and Venters insight was that computational power was just as important to the project as biology. The Human Genome Project was essentially trying to sequence the human genome by finding large chunks of DNA and fitting them together like a jigsaw, finding which bits unambiguously matched up.
Venters idea was that you could do the same with small chunks of DNA, if you approached it as a computational problem and used computers to try/evaluate/reject the millions of ways the pieces could be fit together. So he recruited mathematicians, computer scientists etc and got them to work on the problem. He speeded the project up massively by making the biology bits simpler (smaller pieces of DNA) and shifting the effort to the computational problem.
So he made a big difference. And his insight that it was a computational problem is kindof obvious now but it wasn't obvious 25 years ago.
flobosg
How Perl Saved the Human Genome Project: https://bioperl.org/articles/How_Perl_saved_human_genome.htm...
epistasis
It was very obvious that it was a computational problem, all DNA analysis was highly computational then, as it is now. His guess was that ~500bp fragments would be enough to get a usable assembly.
But the Human Genome Project's approach of reconstructing larger chunks first was also feasible, and produced an assembly too, with a heroic four weeks effort of a former game programmer who even built cluster software at the same time.
xyhopguy
He wasn't the only one who saw the problem computationally. Famously, the mathematician Michael Waterman sat on the other-side of the race for the human genome.
rwmj
He was known informally as the Venterpillar.
peterfirefly
Involved in the sense that his method worked and the one the Human Genome Project insisted on didn't. In the end, they had to use his method to catch up enough that everybody could pretend they did it together and collaboratively -- even though Venter clearly got there first. Venter deserved a Nobel Prize for that and, quite frankly, the Human Genome Project guys deserved a firing.
dnautics
i believe he also was the human genome project, he arranged to have one of the samples be him
jltsiren
Craig Venter had his genome sequenced in 2007. It was the first individual human genome that was sequenced and released publicly.
The human reference genome is ~70% from a man with African and European ancestry who lived somewhere around Buffalo, NY. Most of the rest is from ~20 other individuals in the same area. They were supposed to sequence the samples more evenly, but apparently there were some technical reasons that made them prioritize a single sample.
dekhn
The majority of the genomic sequencing done by Celera for their initial released draft genome was on Venter's sample.
eweitz
"RP11" is that man from Buffalo who comprises 74% of the human reference genome [1].
[1] https://undark.org/2024/07/09/informed-consent-human-genome-...
tootie
I worked on this back in the 90s and there multiple data sets being used. We had one that was Mennonite family with like 5 living generations and 100ish individuals.
acmj
You are confused by the human genome project vs the celera genome project. No, the human genome project didn't include his sample.
mbreese
It gets a little fuzzy when talking about Celera and the human genome project. The two efforts were very much competitors, but there was a lot of crossover (mainly from Celera pulling in the public data).
But, Venter claimed that he was the a good chunk of the genome that Celera sequenced, so I think it's fair to say he was one of the people included in the draft human genome (at least the Celera version of it).
> After leaving Celera in 2002, Venter announced that much of the genome that had been sequenced there was his own. [1]
[1] https://www.technologyreview.com/2007/09/04/223919/craig-ven...
moralestapia
Yes, his was the first complete genome ever sequenced (by a private entity).
schoen
This reminds me of the interesting fact that
> Linnaeus is designated as the type specimen for the human species, Homo sapiens.
timcobb
RIP Craig Venter.
I remember being in 5th grade and hearing about the Human Genome Project. It was presented as a radical undertaking. 30 years later, look how far we've come. Just the other day I was reading about the UK Biobank leaks (https://news.ycombinator.com/item?id=47875843), and it was mentioned that some large number of complete human genomes were leaking out. And I thought wow, back in the day people thought Craig Venter was out there.
Thank you Craig Venter!
rdl
He was pretty shockingly an entrepreneur and inventor in all the best ways,’in a field dominated by very cautious scientists (who are great too, but who likely never would have gotten the genome sequenced within 10-20 years of when he did it). It was basically the Apollo Project in a field which was more like 1980s NASA in culture.
dnautics
iiuc it was hamilton smith who insisted that shotgun sequencing would work. the nih side insisted on primer walking until celera started assembling the genome so rapidly that the nih had to get in on shotgun too
elmolino89
I belive you are mixing assembling the genome by combining sequences of individual, overlapping inserts of cosmids, fosmids, PACs and BACs (bacterial vectors with human DNA inserts of 40-150kbp) to whole genome shotgun. The inserts of the above bacterial vectors were sequenced using shotgun, but the gaps in the sequence were closed with custom primers.
acmj
No, at initial release, the human genome from the NIH side was done by bac-to-bac, not by shotgun.
echelon
> in a field dominated by very cautious scientists (who are great too, but who likely never would have gotten the genome sequenced within 10-20 years of when he did it).
I did a bio undergrad and one of my professors was involved. She was adamant that the Human Genome Project finished ahead of Celera and that the HGP published reference data that Venter and team fundamentally relied upon to even have their shotgun approach work.
dnautics
i worked for ham smith and my understanding through him is that both sides relied on data that the other produced.
here are technical details, both were more or less independent, the celera sequence did include data from the other side as useful reference points but the assembly would have happened without it. https://pmc.ncbi.nlm.nih.gov/articles/PMC123615/
t0mpr1c3
A world-class (and possibly universe-class) egotist who published the first diploid human genome sequence. It was his own DNA. He did not stop at broadcasting his achievement to a human audience: "Since my own genome was sequenced, my software has been broadcast into space in the form of electromagnetic waves, carrying my genetic information far beyond Earth."
kridsdale3
I can't think of a better manifestation of the biological male imperitive.
jwilliams
Sad news. I met Craig very briefly at a conference probably a decade back. I pretty much was a self-study in genetics at the time... so let's just say I wasn't in Craig's league. Despite this he was very engaged and took the time for a very thoughtful chat.
E-Reverance
Interesting comment from him:
"
SPIEGEL: So you don't consider Collins to be a true scientist?
Venter: Let's just say he's a government administrator.
"
https://www.science.org/content/blog-post/craig-venter-venti...
randogp
At the time they announced the full genome sequence I was an intern in molecular biology. We had a thermocycler in the lab and I had to book my slot on a paper agenda. I remember this portrait of him in front of multiple racks each plenty of thermocyclers. He taught me something about scale and he proved that sometimes it's worth looking at what you have and ask what if I could 200x this. In software this might seem obvious with GPU arrays etc.. but when you are trained in a wet lab and the instrument paper agenda, I wonder if we could have more breakthroughs in life sciences if we could use some bruteforce now and then. RIP
CrazyStat
I'm a statistician. My wife does basic (biological) science. Almost every time she asks my advice on an experiment I want to tell her to 10x the sample size. But the academic community has certain ideas about how big sample sizes should be, and trying to use radically larger samples runs into all sorts of barriers ranging from ethics concerns (for animal experiments) to funding.
At the end of the day there's only so much you can learn from a sample size of 12. I'm not sure it's more ethical to have a bunch of wasted experiments with 12 mice each where you don't learn anything than to use 100 mice and actually have statistical power to identify something other than the hugest effect sizes.
elmolino89
Lack of appropriate funding leads to cutting corners to the point that some results may not be worth the price of the paper to describe them. I had a passing experience with epigenetics. Even experiments with basically free of ethics issues cell lines could be screwed up by using single end, too short sequencing reads. Combined with too low coverage, less than perfect controls it gives the input data I which the state of the art peak callers will just throw the towel. So the "trick" is to use some way more forgiving peak caller and get a rather crappy results. Using the outdated human genome assembly (hg19), and old genome mapping programs just puts an extra cherry on the cake...
waiquoo
I'm in lab automation, we've come a long way from paper schedules (although those still get plenty of use :) )
TuringNYC
RIP. I absolutely loved the book A Life Decoded: My Genome: My Life by J. Craig Venter.
crispyambulance
RIP. He was an amazing human. I worked for a time at JCVI when it was in Rockville, shortly after he had left Celera Genomics. He led a team that did something which was considered intractably difficult-- sequencing whole genomes. Then he did it again with global ocean sampling and synthetic genomics and other things. That is not to say that "he did it single-handedly", Venter was a hybrid of scientific and organizational talent that was able to make this stuff happen by coordinating stuff that's super hard to coordinate.
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I raced with him on his boat. During a gybe once, he was swept overboard and the mainsheet wrapped around his torso. He was dragged through the water, but somehow held onto the rail until I was able to pull him back aboard by the loop on his foullies.
He was an interesting guy. He had been a medic during the Vietnam War, and his old boat, Sorcerer II, became a platform for his Global Ocean Sampling Expedition from 2003 to 2010, which discovered millions of new marine microbial genes.
He collected a lot of friends, and definitely a few enemies, and, in his own strange and remarkable way, seemed to have lived a complete human experience here on Earth.